Impact of bilirubin-induced neurologic dysfunction on neurodevelopmental outcomes
نویسندگان
چکیده
منابع مشابه
Impact of bilirubin-induced neurologic dysfunction on neurodevelopmental outcomes.
Bilirubin-induced neurologic dysfunction (BIND) is the constellation of neurologic sequelae following milder degrees of neonatal hyperbilirubinemia than are associated with kernicterus. Clinically, BIND may manifest after the neonatal period as developmental delay, cognitive impairment, disordered executive function, and behavioral and psychiatric disorders. However, there is controversy regard...
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OBJECTIVE The aim of this study was to evaluate the bilirubin albumin (B/A) ratio in comparison with total serum bilirubin (TSB) for predicting acute bilirubin-induced neurologic dysfunction (BIND). METHODS Fifty two term and near term neonates requiring phototherapy and exchange transfusion for severe hyperbilirubinemia in Children's Medical Center, Tehran, Iran, during September 2007 to Sep...
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Excessive metal accumulation in the nervous system may be toxic, inducing oxidative stress, disrupting mitochondrial function, and impairing the activity of numerous enzymes. Damage caused by metal excess may result in permanent injuries, including severe neurological disorders. The immature and strikingly vulnerable neurons play an important role in the pathogenesis of bilirubin-induced neurol...
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On the basis of abundant research data and hypotheses the BIND is a neurodegenerative disease (ND) of immature brain caused by accumulation of free copper ions, unconjugated bilirubin (UCB), and UCB-Cu complex (as prooxidant), respectively, in the basal ganglia (BG) and other parts of the central nervous system (CNS) relevant to BIND. The main comorbidity is the hemolysis of neonatal red blood ...
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ژورنال
عنوان ژورنال: Seminars in Fetal and Neonatal Medicine
سال: 2015
ISSN: 1744-165X
DOI: 10.1016/j.siny.2014.12.003